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Article

CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes.

The Journal of toxicological sciences - 1 Jan 2013

Okubo Maho, Murayama Norie, Shimizu Makiko, Shimada Tsutomu, Guengerich F Peter, Yamazaki Hiroshi

Abstract excerpt

Effects of the CYP3A4 intron 6 C>T (CYP3A4*22) polymorphism, which has recently been reported to have a critical role in vivo, were investigated by measuring CYP3A4 protein expression levels and CYP3A4-dependent drug oxidation activities in individual human liver microsomes in vitro. Prior to protein analysis, analysis of DNA samples indicated that 36 Caucasian subjects were genotyped as CYP3A4*1/*1 and five...

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Identifiers

PMID: 23665933
DOI: 10.2131/jts.38.349
PMCID: PMC4018728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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