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Article

Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes.

Basic & clinical pharmacology & toxicology - 1 Feb 2019

Storelli Flavia, Desmeules Jules, Daali Youssef

Abstract excerpt

Cytochrome P450 (CYP) 2D6 metabolizes a wide range of xenobiotics and is characterized by a huge interindividual variability. A recent clinical study highlighted differential magnitude of CYP inhibition as a function of CYP2D6 genotype. The aim of this study was to investigate the effect of CYP2D6 genotype on the inhibition of dextromethorphan O-demethylation by duloxetine and paroxetine in human liver microsomes...

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Source

Identifiers

PMID: 30192434
DOI: 10.1111/bcpt.13124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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