Article
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.
American journal of human genetics - 1 Jul 2002
Osier Michael V, Pakstis Andrew J, Soodyall Himla, Comas David, Goldman David, Odunsi Adekunle, Okonofua Friday, Parnas Josef, Schulz Leslie O, Bertranpetit Jaume, Bonne-Tamir Batsheva, Lu Ru-Band, Kidd Judith R, Kidd Kenneth K
Abstract excerpt
Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be associated with an effect that is protective against alcoholism. Previous work from our laboratory has shown that the two sites showing the association are in linkage disequilibrium and has identified the ADH1B Arg47His site as causative, with the ADH1C Ile349Val site showing association only because of the disequilibrium. Here,...
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