Article
Diversification of the ADH1B gene during expansion of modern humans.
Annals of human genetics - 1 Jul 2011
Li Hui, Gu Sheng, Han Yi, Xu Zhi, Pakstis Andrew J, Jin Li, Kidd Judith R, Kidd Kenneth K
Abstract excerpt
A variant allele, ADH1B*48His, also known as ADH1B*2, at the human Alcohol Dehydrogenase 1B gene (ADH1B) is strongly associated with alcoholism in some populations and has an unusual geographic distribution. Strong evidence implies selection has increased the frequency of this allele in some East Asian populations but does not fully explain its geographic pattern. We have studied haplotypes of 10 single...
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