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Article

Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.

American journal of human genetics - 1 Jun 2006

Luo Xingguang, Kranzler Henry R, Zuo Lingjun, Wang Shuang, Schork Nicholas J, Gelernter Joel

Abstract excerpt

The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and alcohol dependence (AD) have long been studied in many populations, but not comprehensively. In the present study, we genotyped 16 markers within the ADH gene cluster (including the ADH1A, ADH1B, ADH1C, ADH5, ADH6, and...

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Source

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Identifiers

PMID: 16685648
DOI: 10.1086/504113
PMCID: PMC1474098

Genes

ALDH2
ADH5
ADH7
ADH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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