Article
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.
American journal of human genetics - 1 Apr 1999
Osier M, Pakstis A J, Kidd J R, Lee J F, Yin S J, Ko H C, Edenberg H J, Lu R B, Kidd K K
Abstract excerpt
Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode known functional variants that act on alcohol with different efficiencies. Variants at both these genes have been implicated in alcoholism in some populations because allele frequencies differ between alcoholics and controls. Specifically, controls have higher frequencies of the variants with higher Vmax (ADH2*2 and ADH3*1). In...
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Alleles
- Base Sequence
- China
- Chromosomes, Human, Pair 4
- Cloning, Molecular
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Haplotypes
- Humans
- Indians, Central American
- Linkage Disequilibrium