Article
The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination.
Annals of human genetics - 1 Mar 2004
Oota Hiroki, Pakstis Andrew J, Bonne-Tamir Batsheva, Goldman David, Grigorenko Elena, Kajuna Sylvester L B, Karoma Nganyirwa J, Kungulilo Selemani, Lu Ru-Band, Odunsi Kunle, Okonofua Friday, Zhukova Olga V, Kidd Judith R, Kidd Kenneth K
Abstract excerpt
The catalytic deficiency of human aldehyde dehydrogenase 2 (ALDH2) is caused by a nucleotide substitution (G1510A; Glu487Lys) in exon 12 of the ALDH2 locus. This SNP, and four non-coding SNPs, including one in the promoter, span 40 kb of ALDH2; these and one downstream STRP have been tested in 37 worldwide populations. Only four major SNP-defined haplotypes account for almost all chromosomes in all populations. A...
Topics
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Alleles
- Animals
- Evolution, Molecular
- Gene Frequency
- Genetic Drift
- Genotype
- Haplotypes