Article
Rare ADH variant constellations are specific for alcohol dependence.
Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000
Zuo Lingjun, Zhang Heping, Malison Robert T, Li Chiang-Shan R, Zhang Xiang-Yang, Wang Fei, Lu Lingeng, Lu Lin, Wang Xiaoping, Krystal John H, Zhang Fengyu, Deng Hong-Wen, Luo Xingguang
Abstract excerpt
AIMS: Some of the well-known functional alcohol dehydrogenase (ADH) gene variants (e.g. ADH1B*2, ADH1B*3 and ADH1C*2) that significantly affect the risk of alcohol dependence are rare variants in most populations. In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and...
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