Isolation of a novel mouse variant of the drs tumor suppressor gene.

doi:10.1016/s0304-3835(02)00161-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Isolation of a novel mouse variant of the drs tumor suppressor gene.

Cancer letters - 8 Sept 2002

Kawai Takao, Suzuki Yasuhiko, Yamashita Atsuko, Inoue Hirokazu

Abstract excerpt

The drs gene was isolated as a transformation suppressor against the v-src oncogene. Drs protein has a transmembrane domain and three consensus repeats (CRs) called Sushi motifs in the extracellular domain. The drs gene also has the ability to suppress anchorage-independent growth of human cancer cell lines. In this paper, we report the isolation of a novel variant cDNA of mouse drs (mDRS-2) containing two CRs,...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Cell Division
Female
Gene Library
Genes, Tumor Suppressor
Genes, src
Genetic Variation
Genetic Vectors
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Mice, Mutant Strains

Molecular Sequence Data

Ovary

Retroviridae

Source

Open in PubMed

Identifiers

PMID: 12049817
DOI: 10.1016/s0304-3835(02)00161-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation of a novel mouse variant of the drs tumor suppressor gene.PMID 12049817Read ↗

Isolation of a novel mouse gene, mSVS-1/SUSD2, reversing tumorigenic phenotypes of cancer cells in vitro.Semantic proximity Read ↗

Suppression of anchorage-independent growth of human cancer cell lines by the drs gene.Semantic proximity Read ↗

Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.Semantic proximity Read ↗

Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation.Semantic proximity Read ↗

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.Semantic proximity Read ↗

Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans.Semantic proximity Read ↗

Identification of Smyd4 as a Potential Tumor Suppressor Gene Involved in Breast Cancer DevelopmentSemantic proximity Read ↗

ARMET is a Soluble ER Protein Induced by the Unfolded Protein Response via ERSE-II ElementSemantic proximity Read ↗

Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteinsSemantic proximity Read ↗

The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling.Semantic proximity Read ↗

Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformation.Semantic proximity Read ↗

Identification and characterization of the murine ortholog <i>(brms1)</i> of breast‐cancer metastasis suppressor 1 <i>(BRMS1)</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.