Article
Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
Carcinogenesis - 1 Apr 2007
Tambe Yukihiro, Yoshioka-Yamashita Atsuko, Mukaisho Ken-ichi, Haraguchi Seiki, Chano Tokuhiro, Isono Takahiro, Kawai Takao, Suzuki Yasuhiko, Kushima Ryoji, Hattori Takanori, Goto Motohito, Yamada Shuichi, Kiso Makoto, Saga Yumiko, Inoue Hirokazu
Abstract excerpt
The drs gene was originally isolated as a suppressor of v-src transformation. Expression of drs mRNA is markedly downregulated in a variety of human cancer cell lines and tissues, suggesting the potential role of this gene as a tumor suppressor. Previously, we found that Drs protein associates with ASY/Nogo-B/RTN-x(S), an apoptosis-inducing protein in the endoplasmic reticulum, and sequentially activates caspases...
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