Article
Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.
Journal of virology - 1 Feb 2003
Kim Rachel, Trubetskoy Alla, Suzuki Takeshi, Jenkins Nancy A, Copeland Neal G, Lenz Jack
Abstract excerpt
The identification of tumor-inducing genes is a driving force for elucidating the molecular mechanisms underlying cancer. Many retroviruses induce tumors by insertion of viral DNA adjacent to cellular oncogenes, resulting in altered expression and/or structure of the encoded proteins. The availability of the mouse genome sequence now allows analysis of retroviral common integration sites in murine tumors to be...
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