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Article

Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformation.

The Journal of biological chemistry - 24 Jul 1998

Foos G, García-Ramírez J J, Galang C K, Hauser C A

Abstract excerpt

Ets transcription factors are important downstream targets of oncogenic Ras. The transcriptional activity of several Ets family members is regulated by Ras, and interfering with Ets-dependent transcription by expression of just the Ets2 DNA binding domain can inhibit or reverse Ras-mediated cellu...

Topics

3T3 Cells
Animals
Binding Sites
Cell Transformation, Neoplastic
DNA
DNA-Binding Proteins
Genes, ras
Humans
Mice
Phenotype
Proto-Oncogene Protein c-ets-2
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

Trans-Activators

Transcription Factors

Source

Identifiers

PMID: 9668063
DOI: 10.1074/jbc.273.30.18871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9668063-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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