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Article

Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor.

British journal of pharmacology - 1 Jul 2000

Costa-Neto C M, Miyakawa A A, Oliveira L, Hjorth S A, Schwartz T W, Paiva A C

Abstract excerpt

1. The role of different residues of the rat AT(1A) receptor in the interaction with the N- and C-terminal ends of angiotensin II (AngII) was studied by determining ligand binding and production of inositol phosphates (IP) in COS-7 cells transiently expressing the following AT(1A) mutants: T88H, Y92H, G196I, G196W and D278E. 2. G196W and G196I retained significant binding and IP-production properties, indicating...

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Identifiers

PMID: 10903964
DOI: 10.1038/sj.bjp.0703430
PMCID: PMC1572190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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