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Article

Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD.

FEBS letters - 31 Mar 2000

Miura S, Zhang J, Karnik S S

Abstract excerpt

To explore peptide hormone-induced conformational changes, we attempted to engineer a metal-ion binding site between the cytoplasmic loops CD and EF in the angiotensin II type 1 (AT(1)) receptor. We constructed 12 double and six triple histidine mutant receptors, and tested the ability of each mutant and the wild-type to activate inositol phosphate (IP) production with and without ZnCl(2). Inhibition by ZnCl(2)...

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Source

Identifiers

PMID: 10745091
DOI: 10.1016/s0014-5793(00)01346-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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