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Article

Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation.

Journal of cell science - 15 Jun 2002

Hirose Tomonori, Izumi Yasushi, Nagashima Yoji, Tamai-Nagai Yoko, Kurihara Hidetake, Sakai Tatsuo, Suzuki Yukari, Yamanaka Tomoyuki, Suzuki Atsushi, Mizuno Keiko, Ohno Shigeo

Abstract excerpt

The mammalian protein ASIP/PAR-3 interacts with atypical protein kinase C isotypes (aPKC) and shows overall sequence similarity to the invertebrate proteins C. elegans PAR-3 and Drosophila Bazooka, which are crucial for the establishment of polarity in various cells. The physical interaction between ASIP/PAR-3 and aPKC is also conserved in C. elegans PAR-3 and PKC-3 and in Drosophila Bazooka and DaPKC. In...

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Source

Identifiers

PMID: 12045219
DOI: 10.1242/jcs.115.12.2485

Genes

ASIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation.PMID 12045219Read ↗

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM).Semantic proximity Read ↗

Par‐3 family proteins in cell polarity & adhesionSemantic proximity Read ↗

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.Semantic proximity Read ↗

PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.Semantic proximity Read ↗

aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization.Semantic proximity Read ↗

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.Semantic proximity Read ↗

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.Semantic proximity Read ↗

Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Par3A and Par3B orchestrate podocyte architecture by regulating RhoA levelsSemantic proximity Read ↗

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells.Semantic proximity Read ↗

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