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Article

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

Current biology : CB - 24 Aug 2004

Suzuki Atsushi, Hirata Maki, Kamimura Katsusi, Maniwa Rika, Yamanaka Tomoyuki, Mizuno Keiko, Kishikawa Masaru, Hirose Hiroko, Amano Yoshiko, Izumi Natsuko, Miwa Yoshihiro, Ohno Shigeo

Abstract excerpt

BACKGROUND: aPKC and PAR-1 are required for cell polarity in various contexts. In mammalian epithelial cells, aPKC localizes at tight junctions (TJs) and plays an indispensable role in the development of asymmetric intercellular junctions essential for the establishment and maintenance of apicobasal polarity. On the other hand, one of the mammalian PAR-1 kinases, PAR-1b/EMK1/MARK2, localizes to the lateral...

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Source

Identifiers

PMID: 15324659
DOI: 10.1016/j.cub.2004.08.021

Genes

MARK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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