Article
PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.
Development (Cambridge, England) - 1 Jun 2010
Achilleos Annita, Wehman Ann M, Nance Jeremy
Abstract excerpt
The apicobasal polarity of epithelial cells is critical for organ morphogenesis and function, and loss of polarity can promote tumorigenesis. Most epithelial cells form when precursor cells receive a polarization cue, develop distinct apical and basolateral domains and assemble junctions near their apical surface. The scaffolding protein PAR-3 regulates epithelial cell polarity, but its cellular role in the...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Base Sequence
- Cadherins
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Polarity
- DNA, Helminth
- Epithelial Cells
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Intercellular Junctions