Article
Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2002
Mishima Aki, Suzuki Atsushi, Enaka Makiko, Hirose Tomonori, Mizuno Keiko, Ohnishi Tetsuo, Mohri Hiroshi, Ishigatsubo Yoshiaki, Ohno Shigeo
Abstract excerpt
BACKGROUND: PAR-3 is one of the PAR proteins, previously named ASIP, which are indispensable for the establishment of cell polarity in the embryo as well as differentiated epithelial cells. In mammalian epithelial cells, it forms a ternary complex with aPKC and PAR-6, and is localized to the tight junction that has been suggested as being important for creating cell polarity. RESULTS: To gain insights into the...
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