Article
Acute cardiac transplant rejection is associated with low frequencies of interleukin-4 producing helper T-lymphocytes rather than with interleukin-4 promoter or splice variants.
Human immunology - 1 Apr 2002
Bijlsma Femke J, van Kuik Joyce, van Hoffen Els, de Jonge Nicolaas, Tilanus Marcel G J, Gmelig-Meyling Frits H J, de Weger Roel A
Abstract excerpt
Interleukin-4 (IL-4) is a cytokine of the Th2 subtype. It is suggested that Th2 cytokines are involved in induction of tolerance towards the graft after organ transplantation. Therefore, we studied the association between the frequencies of IL-4 producing helper T lymphocytes (IL-4 HTL) and acute rejection in a panel of 31 cardiac transplant patients. It was also investigated whether these frequencies were...
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