Article
Polymorphisms in the T cell regulatory gene cytotoxic T lymphocyte antigen 4 influence the rate of acute rejection after liver transplantation.
Gut - 1 Jun 2006
Tapirdamaz O, Pravica V, Metselaar H J, Hansen B, Moons L, van Meurs J B J, Hutchinson I V, Shaw J, Agarwal K, Adams D H, Day C P, Kwekkeboom J
Abstract excerpt
BACKGROUND: The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene encodes for a membrane bound (mCTLA-4) and a soluble (sCTLA-4) isoform, which are both involved in regulation of T cell function. The CTLA-4 +49A/G single nucleotide polymorphism (SNP) influences expression of mCTLA-4; +6230G/A SNP affects the production of sCTLA-4. AIM: To examine whether these functional SNPs influence the rate of rejection after...
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