Article
No association between transforming growth factor beta gene polymorphism and acute allograft rejection after cardiac transplantation.
Transplant immunology - 1 Jun 2002
Bijlsma Femke J, van der Horst Armando A, Tilanus Marcel G J, Rozemuller Erik, de Jonge Nicolaas, Gmelig-Meyling Frits H J, de Weger Roel A
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine, which inhibits both development of Th1 and Th2 subsets and the Th1 proinflammatory response. TGF-beta1 production is influenced through several single nucleotide polymorphisms (SNP) in the structural gene and promoter region. Acute rejection of transplants depends on the Th1/Th2 balance within the graft, high levels of TGF-beta1 shift...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.