Article
The 14-bp deletion in the HLA-G gene indicates a low risk for acute cellular rejection in heart transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jul 2011
Twito Tal, Joseph Jemy, Mociornita Amelia, Rao Vivek, Ross Heather, Delgado Diego H
Abstract excerpt
BACKGROUND: Human leukocyte antigen G (HLA-G) is a non-classical Ib molecule in the major histocompatibility complex. HLA-G has important immunosuppressive properties, and in the context of cardiac transplantation, is associated with a low risk of cellular rejection. A 14-bp insertion/deletion polymorphism in exon 8 of the HLA-G gene is associated with messenger RNA (mRNA) stability and expression of HLA-G. This...
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