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Article

Donor interleukin-4 promoter gene polymorphism influences allograft rejection after heart transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Mar 2002

Bijlsma Femke J, vanKuik Joyce, Tilanus Marcel G J, deJonge Nicolaas, Rozemuller Erik H, van den Tweel Jan G, Gmelig-Meyling Frits H J, deWeger Roel A

Abstract excerpt

BACKGROUND: The cytokine interleukin-4 (IL-4) is secreted mainly by activated T lymphocytes and characterizes the T-helper 2 (Th2) sub-type. In transplantation Th2 cells are believed to induce graft tolerance. Previous studies revealed that patients with a relatively high frequency of IL-4 producing helper T lymphocytes (HTL) before heart transplantation (HTX) had no or less rejection episodes compared with...

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Identifiers

PMID: 11897522
DOI: 10.1016/s1053-2498(01)00386-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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