Article
Functions of lumican and fibromodulin: lessons from knockout mice.
Glycoconjugate journal - 1 Jan 2000
Chakravarti Shukti
Abstract excerpt
Lumican and fibromodulin are collagen-binding leucine-rich proteoglycans widely distributed in interstitial connective tissues. The phenotypes of lumican-null (Lum(-/-)), Fibromodulin-null (Fmod(-/-)) and compound double-null (Lum(-/-)Fmod(-/-)) mice identify a broad range of tissues where these two proteoglycans have overlapping and unique roles in modulating the extracellular matrix and cellular behavior. The...
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