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Article

Role of Cys41 in the N-terminal domain of lumican in ex vivo collagen fibrillogenesis by cultured corneal stromal cells.

The Biochemical journal - 1 Feb 2003

Carlson Eric C, Mamiya Kazuhisa, Liu Chia-Yang, Gendron Robert L, Birk David E, Funderburgh James L, Kao Winston W-Y

Abstract excerpt

The keratan sulphate proteoglycan lumican regulates collagen fibrillogenesis to maintain the integrity and function of connective tissues such as cornea. We examined the role of a highly conserved cysteine-containing domain proximal to the N-terminus of lumican in collagen fibrillogenesis using site-specific mutagenesis to prepare plasmid DNA encoding wild-type murine lumican...

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Identifiers

PMID: 12381269
DOI: 10.1042/BJ20020593
PMCID: PMC1223108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of Cys41 in the N-terminal domain of lumican in ex vivo collagen fibrillogenesis by cultured corneal stromal cells.PMID 12381269Read ↗

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Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model.Semantic proximity Read ↗

Ocular and Scleral Alterations in Gene-Targeted Lumican-Fibromodulin Double-Null MiceSemantic proximity Read ↗

Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea SyndromeSemantic proximity Read ↗

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Response of Lens Epithelial Cells to Injury: Role of Lumican in Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

An x-ray diffraction investigation of corneal structure in lumican-deficient mice.Semantic proximity Read ↗

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