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Article

Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.

Cancer research - 1 Jun 2002

Gao Qingshen, Kumar Ajay, Singh Latika, Huibregtse Jon M, Beaudenon Sylvie, Srinivasan Seetha, Wazer David E, Band Hamid, Band Vimla

Abstract excerpt

High-risk human papilloma viruses are known to be associated with cervical cancers. We have reported previously that the high-risk human papillomavirus (HPV) E6 oncoprotein interacts with E6TP1, a novel Rap GTPase-activating protein (RapGAP). Similar to p53 tumor suppressor protein, the high-risk HPV E6 oncoproteins target E6TP1 for degradation. The HPV16 E6-induced degradation of E6TP1 strongly correlates with...

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PMID: 12036950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.PMID 12036950Read ↗

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