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Article

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.

Journal of virology - 1 Jul 2000

Kao W H, Beaudenon S L, Talis A L, Huibregtse J M, Howley P M

Abstract excerpt

The E6 protein of the high-risk human papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which causes the ubiquitination and degradation of p53. We show here that HPV16 E6 promotes the ubiquitination and degradation of E6AP itself. The half-life of E6AP is short...

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Identifiers

PMID: 10864652
DOI: 10.1128/jvi.74.14.6408-6417.2000
PMCID: PMC112148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10864652-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.PMID 10864652Read ↗

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