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E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence

7 Feb 2025

Abstract excerpt

Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The formation of a trimeric complex between the HPV E6 oncoprotein, the cellular ubiquitin ligase E6AP and the p53 tumor suppressor protein leads to proteolytic p53 degradation and plays a central role for HPV-induced cell transformation. We here uncover that E6AP silencing in HPV-positive cancer cells ultimately leads to efficient...

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PMID: 39919145
DOI: 10.1371/journal.ppat.1012914

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