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Article

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.

Journal of virology - 1 Jan 2012

Mesplède Thibault, Gagnon David, Bergeron-Labrecque Fanny, Azar Ibrahim, Sénéchal Hélène, Coutlée François, Archambault Jacques

Abstract excerpt

Human papillomaviruses (HPVs) are the etiological agents of cervical cancer and other human malignancies. HPVs are classified into high- and low-risk genotypes according to their association with cancer. Host cell transformation by high-risk HPVs relies in part on the ability of the viral E6 protein to induce the degradation of p53. We report the development of a cellular assay that accurately quantifies the p53...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oncogene Proteins, Viral

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Source

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Identifiers

PMID: 22013048
DOI: 10.1128/JVI.00751-11
PMCID: PMC3255875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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