Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.

The Journal of biological chemistry - 18 Mar 2005

Liu Xuefeng, Yuan Hang, Fu Baojin, Disbrow Gary L, Apolinario Tania, Tomaic Vjekoslav, Kelley Melissa L, Baker Carl C, Huibregtse Jon, Schlegel Richard

Abstract excerpt

Most human cancer cells display increased telomerase activity that appears to be critical for continued cell proliferation and tumor formation. The E6 protein of malignancy-associated human papillomaviruses increases cellular telomerase in primary human keratinocytes at least partly via transcrip...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Keratinocytes

Share to Luciferases

Share to Oncogene Proteins, Viral

Share to Proto-Oncogene Proteins c-myc

Share to Ubiquitin

Source

Identifiers

PMID: 15655249
DOI: 10.1074/jbc.M410343200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15655249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.PMID 15655249Read ↗

HPV E6 protein interacts physically and functionally with the cellular telomerase complexSemantic proximity Read ↗

The Global Transcriptional Effects of the Human Papillomavirus E6 Protein in Cervical Carcinoma Cell Lines Are Mediated by the E6AP Ubiquitin LigaseSemantic proximity Read ↗

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 OncoproteinSemantic proximity Read ↗

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.Semantic proximity Read ↗

Cell-Restricted Immortalization by Human Papillomavirus Correlates with Telomerase Activation and Engagement of the hTERT Promoter by MycSemantic proximity Read ↗

HPV16 E7 Protein and hTERT Proteins Defective for Telomere Maintenance Cooperate to Immortalize Human KeratinocytesSemantic proximity Read ↗

E6-Associated Protein Is Required for Human Papillomavirus Type 16 E6 to Cause Cervical Cancer in MiceSemantic proximity Read ↗

HPV16‐E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300Semantic proximity Read ↗

Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding SitesSemantic proximity Read ↗

E Box-Dependent Activation of Telomerase by Human Papillomavirus Type 16 E6 Does Not Require Induction of c- mycSemantic proximity Read ↗

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.Semantic proximity Read ↗

Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.