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Article

Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells

1 Sept 1999

Abstract excerpt

The E6 proteins from cervical cancer-associated human papillomavirus (HPV) types such as HPV type 16 (HPV-16) induce proteolysis of the p53 tumor suppressor protein through interaction with E6-AP. We have previously shown that human mammary epithelial cells (MECs) immortalized by HPV-16 E6 display low levels of p53. HPV-16 E6 as well as other cancer-related papillomavirus E6 proteins also binds the cellular...

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Identifiers

PMID: 10438818
DOI: 10.1128/jvi.73.9.7297-7307.1999

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Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial CellsPMID 10438818Read ↗

Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cellsSemantic proximity Read ↗

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.Semantic proximity Read ↗

The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for DegradationSemantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Semantic proximity Read ↗

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrestSemantic proximity Read ↗

Comparative Analysis of 19 Genital Human Papillomavirus Types with Regard to p53 Degradation, Immortalization, Phylogeny, and Epidemiologic Risk ClassificationSemantic proximity Read ↗

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.Semantic proximity Read ↗

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cellsSemantic proximity Read ↗

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.Semantic proximity Read ↗

A Critical Role for p53 during the HPV16 Life CycleSemantic proximity Read ↗

E6-Associated Protein Is Required for Human Papillomavirus Type 16 E6 to Cause Cervical Cancer in MiceSemantic proximity Read ↗

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