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HPV E6 protein interacts physically and functionally with the cellular telomerase complex

20 Oct 2009

Abstract excerpt

Telomerase activation is critical for the immortalization of primary human keratinocytes by the high-risk HPV E6 and E7 oncoproteins, and this activation is mediated in part by E6-induction of the hTERT promoter. E6 induces the hTERT promoter via interactions with the cellular ubiquitin ligase, E6AP, and with the c-Myc and NFX-1 proteins, which are resident on the promoter. In the current study we demonstrate...

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PMID: 19843693
DOI: 10.1073/pnas.0906357106

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HPV E6 protein interacts physically and functionally with the cellular telomerase complexPMID 19843693Read ↗

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