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Article

The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for Degradation

1 Jan 1999

Abstract excerpt

The high-risk human papillomaviruses (HPVs) are associated with carcinomas of the cervix and other genital tumors. Previous studies have identified two viral oncoproteins, E6 and E7, which are expressed in the majority of HPV-associated carcinomas. The ability of high-risk HPV E6 protein to immortalize human mammary epithelial cells (MECs) has provided a single-gene model to study the mechanisms of E6-induced...

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PMID: 9858596
DOI: 10.1128/mcb.19.1.733

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Related research

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The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for DegradationPMID 9858596Read ↗

Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.Semantic proximity Read ↗

The High-Risk Human Papillomavirus Type 16 E6 Counters the GAP Function of E6TP1 toward Small Rap G ProteinsSemantic proximity Read ↗

Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial CellsSemantic proximity Read ↗

Novel Functions of the Human Papillomavirus E6 OncoproteinsSemantic proximity Read ↗

Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600Semantic proximity Read ↗

Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cellsSemantic proximity Read ↗

E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescenceSemantic proximity Read ↗

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Semantic proximity Read ↗

A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells.Semantic proximity Read ↗

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activationSemantic proximity Read ↗

Human Papillomavirus Type 16 E6 Amino Acid 83 Variants Enhance E6-Mediated MAPK Signaling and Differentially Regulate Tumorigenesis by Notch Signaling and Oncogenic RasSemantic proximity Read ↗

PKN Binds and Phosphorylates Human Papillomavirus E6 OncoproteinSemantic proximity Read ↗

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