The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

doi:10.1074/jbc.273.11.6439

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Article

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

The Journal of biological chemistry - 13 Mar 1998

Talis A L, Huibregtse J M, Howley P M

Abstract excerpt

The E6 protein encoded by the oncogenic human papillomaviruses (HPVs) targets p53 for ubiquitin-dependent proteolysis. E6-mediated p53 degradation requires the 100-kDa cellular protein E6-associated protein (E6AP). E6AP and E6 together provide the E3-ubiquitin protein ligase activity in the trans...

Topics

Cell Cycle
Half-Life
HeLa Cells
Humans
Ligases
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Protein Binding
Recombinant Proteins
Tumor Suppressor Protein p53
Ubiquitin-Protein Ligases
Ubiquitins

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