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Article

Power and efficiency of the TDT and case-control design for association scans.

Behavior genetics - 1 Mar 2002

McGinnis Ralph, Shifman Sagiv, Darvasi Ariel

Abstract excerpt

Sample size required for the TDT and the case-control designs was studied for marker-based genome-wide scans for disease association. The influence of various parameters on sample size required to attain a given level of power was analyzed in detail. Small genotypic relative risks, low levels of linkage disequilibrium, and departure from equal frequencies for the disease allele and associated marker allele,...

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Identifiers

PMID: 12036111
DOI: 10.1023/a:1015205924326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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