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Article

Power analysis of C-TDT for small sample size genome-wide association studies by the joint use of case-parent trios and pairs.

Computational and mathematical methods in medicine - 1 Jan 2013

Rajabli Farid, Inan Gul, Ilk Ozlem

Abstract excerpt

In family-based genetic association studies, it is possible to encounter missing genotype information for one of the parents. This leads to a study consisting of both case-parent trios and case-parent pairs. One of the approaches to this problem is permutation-based combined transmission disequilibrium test statistic. However, it is still unknown how powerful this test statistic is with small sample sizes. In...

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PMID: 23737858
DOI: 10.1155/2013/235825
PMCID: PMC3659481

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