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Article

Interference with ubiquitination causes oxidative damage and increased protein nitration: implications for neurodegenerative diseases.

Journal of neurochemistry - 1 Jul 2004

Hyun Dong-Hoon, Gray Douglas A, Halliwell Barry, Jenner Peter

Abstract excerpt

Inhibition of the proteasomal pathway for degrading abnormal proteins leads to protein aggregation, increased oxidative damage and increased protein nitration. We now show that interference with polyubiquitination has similar consequences. Expression of a dominant-negative mutant form of ubiquitin (K48R) in NT-2 and SK-N-MC cells caused decreased cell growth rates and increased oxidative damage (protein carbonyls...

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Identifiers

PMID: 15228598
DOI: 10.1111/j.1471-4159.2004.02493.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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