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Article

Parkin suppresses the expression of monoamine oxidases.

The Journal of biological chemistry - 31 Mar 2006

Jiang Houbo, Jiang Qian, Liu Wenhua, Feng Jian

Abstract excerpt

Mutations of parkin are linked to early onset Parkinson disease. Here we show that stable transfection of parkin in the human dopaminergic neuroblastoma cell line SH-SY5Y markedly reduced the activities of both monoamine oxidase (MAO) A and B. The amount of 3,4-dihydroxyphenylacetic acid, which is produced during dopamine oxidation by MAO, was greatly reduced by parkin overexpression. Radioligand binding assays...

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Identifiers

PMID: 16455660
DOI: 10.1074/jbc.M510926200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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