Article
-463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis.
Clinical immunology (Orlando, Fla.) - 1 May 2002
Reynolds Wanda F, Stegeman Coen A, Tervaert Jan W Cohen
Abstract excerpt
Wegener's granulomatosis, microscopic polyangiitis, and Churg Strauss syndrome are forms of systemic vasculitides in which neutrophils and monocyte macrophages infiltrate the walls of small blood vessels, leading to destruction and occlusion. These diseases are associated with autoantibodies directed against granular components of neutrophils and monocytes, i.e., antineutrophil cytoplasmic antibodies (ANCA). The...
Topics
- Antibodies, Antineutrophil Cytoplasmic
- Churg-Strauss Syndrome
- Genotype
- Glomerulonephritis
- Granulomatosis with Polyangiitis
- Humans
- Monocytes
- Neutrophils
- Peroxidase
- Phenotype
- Polymorphism, Genetic
- Vasculitis