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Article

Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction.

Genes & development - 15 May 2002

Gleason Julie E, Korswagen Hendrik C, Eisenmann David M

Abstract excerpt

During Caenorhabditis elegans vulval development, activation of receptor tyrosine kinase/Ras and Notch signaling pathways causes three vulval precursor cells (VPCs) to adopt induced cell fates. A Wnt signaling pathway also acts in cell fate specification by the VPCs, via regulation of the Hox gene lin-39. We show here that either mutation of pry-1 or expression of an activated BAR-1 beta-catenin protein causes an...

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PMID: 12023306
DOI: 10.1101/gad.981602
PMCID: PMC186276

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Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction.PMID 12023306Read ↗

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