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Article

Necessity and Contingency in Developmental Genetic Screens: EGF, Wnt, and Semaphorin Pathways in Vulval Induction of the Nematode Oscheius tipulae.

Genetics - 1 Apr 2019

Vargas-Velazquez Amhed M, Besnard Fabrice, Félix Marie-Anne

Abstract excerpt

Genetic screens in the nematode Caenorhabditis elegans identified the EGF/Ras and Notch pathways as central for vulval precursor cell fate patterning. Schematically, the anchor cell secretes EGF, inducing the P6.p cell to a primary (1°) vulval fate; P6.p in turn induces its neighbors to a secondary (2°) fate through Delta-Notch signaling and represses Ras signaling. In the nematode Oscheius tipulae, the anchor...

Topics

Animals
Epidermal Growth Factor
Female
Gene Expression Regulation, Developmental
Helminth Proteins
Mutation
Nematoda
Semaphorins
Vulva
Wnt Signaling Pathway

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30700527
DOI: 10.1534/genetics.119.301970
PMCID: PMC6456316

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-30700527-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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