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Article

The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction.

Development (Cambridge, England) - 1 Oct 1998

Sommer R J, Eizinger A, Lee K Z, Jungblut B, Bubeck A, Schlak I

Abstract excerpt

In the two nematode species Caenorhabditis elegans and Pristionchus pacificus the vulva equivalence group in the central body region is specified by the Hox gene lin-39. C. elegans lin-39 mutants are vulvaless and the vulval precursor cells fuse with the surrounding hypodermis, whereas in P. pacificus lin-39 mutants the vulval precursor cells die by apoptosis. Mechanistically, LIN-39 might inhibit non-vulval fate...

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PMID: 9729494
DOI: 10.1242/dev.125.19.3865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction.PMID 9729494Read ↗

The homeotic gene lin-39 and the evolution of nematode epidermal cell fates.Semantic proximity Read ↗

Apoptosis and change of competence limit the size of the vulva equivalence group in Pristionchus pacificus: a genetic analysis.Semantic proximity Read ↗

HAIRY-like transcription factors and the evolution of the nematode vulva equivalence group.Semantic proximity Read ↗

The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling.Semantic proximity Read ↗

Vulval developmentSemantic proximity Read ↗

Novel cell-cell interactions during vulva development in Pristionchus pacificus.Semantic proximity Read ↗

Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development.Semantic proximity Read ↗

Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein.Semantic proximity Read ↗

Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences.Semantic proximity Read ↗

sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.Semantic proximity Read ↗

Vulva formation in Pristionchus pacificus relies on continuous gonadal induction.Semantic proximity Read ↗

LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion.Semantic proximity Read ↗

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