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Article

Genetic determinants of Sindbis virus neuroinvasiveness

1 Apr 1997

Abstract excerpt

After peripheral inoculation of mice, Sindbis virus replicates in a variety of tissues, leading to viremia. In some cases, the virus can enter the central nervous system (CNS) and cause lethal encephalitis. The outcome of infection is age and virus strain dependent. Recently, two pairs of Sindbis virus variants differing in neurovirulence and neuroinvasiveness were derived by limited serial passaging in mouse...

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PMID: 9060616
DOI: 10.1128/jvi.71.4.2636-2646.1997

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