Article
Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.
Oncogene - 21 Jun 2001
Huo T I, Wang X W, Forgues M, Wu C G, Spillare E A, Giannini C, Brechot C, Harris C C
Abstract excerpt
Chronic hepatitis B virus (HBV) infection and the integration of its X gene (HBx) are closely associated with the development of hepatocellular carcinoma (HCC). The integrated HBx frequently is truncated or contains point mutations. Previous studies indicated that these HBx mutants have a diminis...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- COS Cells
- Carcinoma, Hepatocellular
- Cell Line
- Chlorocebus aethiops
- Genes, Reporter
- Glutathione Transferase
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Neoplasms
- Luciferases
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Protein Biosynthesis