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Functional analysis of transactivation by mutants of hepatitis B virus X gene in human hepatocellular carcinoma.

Oncology reports - 1 Aug 2005

Minemura Masami, Shimizu Yukihiro, Hirano Katsuharu, Nakayama Yasuhiro, Tokimitsu Yoshiharu, Tajiri Kazuto, Yamada Kazuki, Xue Feng, Takahara Terumi, Watanabe Akiharu, Sugiyama Toshiro

Abstract excerpt

The X protein of the hepatitis B virus transactivates various cellular and viral promoters and enhancers. In this study, wild-type and mutants of the X gene, including the point mutations at codons 130 (AAG-->ATG, lysin-->methionine) and 131 (GTC-->ATC, valine-->isoleucine), commonly found in patients with human hepatocellular carcinoma (HCC), or deletions encompassing the same region, were cloned and inserted...

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PMID: 16012736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Functional analysis of transactivation by mutants of hepatitis B virus X gene in human hepatocellular carcinoma.PMID 16012736Read ↗

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An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver.Semantic proximity Read ↗

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.Semantic proximity Read ↗

The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication.Semantic proximity Read ↗

Transactivation of cellular promoters by an integrated hepatitis B virus DNA.Semantic proximity Read ↗

Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication.Semantic proximity Read ↗

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