Article
Functional analysis of transactivation by mutants of hepatitis B virus X gene in human hepatocellular carcinoma.
Oncology reports - 1 Aug 2005
Minemura Masami, Shimizu Yukihiro, Hirano Katsuharu, Nakayama Yasuhiro, Tokimitsu Yoshiharu, Tajiri Kazuto, Yamada Kazuki, Xue Feng, Takahara Terumi, Watanabe Akiharu, Sugiyama Toshiro
Abstract excerpt
The X protein of the hepatitis B virus transactivates various cellular and viral promoters and enhancers. In this study, wild-type and mutants of the X gene, including the point mutations at codons 130 (AAG-->ATG, lysin-->methionine) and 131 (GTC-->ATC, valine-->isoleucine), commonly found in patients with human hepatocellular carcinoma (HCC), or deletions encompassing the same region, were cloned and inserted...
Topics
- Animals
- Avian Sarcoma Viruses
- Base Sequence
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Cell-Free System
- Genetic Vectors
- Humans
- Molecular Sequence Data
- Mutation