Article
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994
Wang X W, Forrester K, Yeh H, Feitelson M A, Gu J R, Harris C C
Abstract excerpt
Chronic active hepatitis caused by infection with hepatitis B virus, a DNA virus, is a major risk factor for human hepatocellular carcinoma. Since the oncogenicity of several DNA viruses is dependent on the interaction of their viral oncoproteins with cellular tumor-suppressor gene products, we investigated the interaction between hepatitis B virus X protein (HBX) and human wild-type p53 protein. HBX complexes...
Topics
- Cell Line
- DNA
- DNA-Binding Proteins
- Drosophila Proteins
- Humans
- Mutation
- Protein Binding
- Trans-Activators
- Transcription Factors
- Transcriptional Activation