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Article

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994

Wang X W, Forrester K, Yeh H, Feitelson M A, Gu J R, Harris C C

Abstract excerpt

Chronic active hepatitis caused by infection with hepatitis B virus, a DNA virus, is a major risk factor for human hepatocellular carcinoma. Since the oncogenicity of several DNA viruses is dependent on the interaction of their viral oncoproteins with cellular tumor-suppressor gene products, we investigated the interaction between hepatitis B virus X protein (HBX) and human wild-type p53 protein. HBX complexes...

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Identifiers

PMID: 8134379
DOI: 10.1073/pnas.91.6.2230
PMCID: PMC43344

Genes

ERCC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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