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Article

Naturally occurring hepatitis B virus mutants with deletions in the core promoter region.

Journal of hepatology - 1 Jun 1994

Laskus T, Rakela J, Tong M J, Nowicki M J, Mosley J W, Persing D H

Abstract excerpt

A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions...

Topics

Adult
Base Sequence
Chromosome Deletion
Female
Gene Amplification
Hepatitis B
Hepatitis B virus
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Viral Core Proteins

Source

Identifiers

PMID: 7930487
DOI: 10.1016/s0168-8278(05)80158-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7930487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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