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Article

Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos.

Current biology : CB - 14 May 2002

Vidwans Smruti J, DiGregorio Paul J, Shermoen Antony W, Foat Barrett, Iwasa Janet, Yakubovich Nikita, O'Farrell Patrick H

Abstract excerpt

When mitosis is bypassed, as in some cancer cells or in natural endocycles, sister chromosomes remain paired and produce four-stranded diplochromosomes or polytene chromosomes. Cyclin/Cdk1 inactivation blocks entry into mitosis and can reset G2 cells to G1, allowing another round of replication. Reciprocally, persistent expression of Cyclin A/Cdk1 or Cyclin E/Cdk2 blocks Drosophila endocycles. Inactivation of...

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Identifiers

PMID: 12015119
DOI: 10.1016/s0960-9822(02)00845-x
PMCID: PMC2754250

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Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos.PMID 12015119Read ↗

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