Article
no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila.
Development (Cambridge, England) - 1 Feb 2009
Merkle Julie A, Rickmyre Jamie L, Garg Aprajita, Loggins Erin B, Jodoin Jeanne N, Lee Ethan, Wu Louisa P, Lee Laura A
Abstract excerpt
In a screen for cell-cycle regulators, we identified a Drosophila maternal effect-lethal mutant that we named ;no poles' (nopo). Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles during the rapid S-M cycles of syncytial embryogenesis. We identified CG5140, which encodes a candidate RING domain-containing E3 ubiquitin ligase, as the nopo gene. A conserved residue in the...
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