Article
Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.
The EMBO journal - 2 Oct 1995
Sigrist S, Jacobs H, Stratmann R, Lehner C F
Abstract excerpt
While entry into mitosis is triggered by activation of cdc2 kinase, exit from mitosis requires inactivation of this kinase. Inactivation results from proteolytic degradation of the regulatory cyclin subunits during mitosis. At least three different cyclin types, cyclins A, B and B3, associate with cdc2 kinase in higher eukaryotes and are sequentially degraded in mitosis. We show here that mutations in the...
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