Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

doi:10.1002/j.1460-2075.1995.tb00164.x

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Article

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

The EMBO journal - 2 Oct 1995

Sigrist S, Jacobs H, Stratmann R, Lehner C F

Abstract excerpt

While entry into mitosis is triggered by activation of cdc2 kinase, exit from mitosis requires inactivation of this kinase. Inactivation results from proteolytic degradation of the regulatory cyclin subunits during mitosis. At least three different cyclin types, cyclins A, B and B3, associate wit...

Topics

Anaphase
Animals
CDC2 Protein Kinase
Cdc20 Proteins
Cell Cycle Proteins
Cyclin B
Cyclins
Drosophila
Drosophila Proteins
Genes, Insect
Heat-Shock Response
Metaphase
Mitosis
Mutation
Phenotype
Sequence Deletion
Spindle Apparatus
Temperature

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